Liquimax Ammonia-UV

Ammonia , derived from the catabolism of amino acids and from the action of intestinal bacteria on dietary protein , is coverted to urea in the liver hepatocytes and so rendere non toxic . Under normal circumstances the Conc.of ammonia in the circulation remains low, typically less then 90µg/dl. Studies have shown that excess ammonia can have a toxic effect on the central nervous system and clinical manifestations are typically neurological disturbances. Elevated levels ammonia may be either due to :(i) inborn errors of metabolism ; or (ii) secondary to other conditions. Inborn errors of the metabolism are the major cause of elevated ammonia in infants usually the result of urea cycle enzyme enzyme deficiencies. Inherited disorders affecting the metabolism of the dibasic amino acids (lysine and ornithine ) and those involving the metabolism of organic acids may also produce elevated levels of circulating ammonia .Elevated ammonia may also observed in severe liver failure as may occur in Reye’s syndrome,viral hepatitis or cirrhosis.